Creative Biolabs helps you solve the problem of drug resistance. We find novel antibodies and peptides that make resistant cells sensitive to drugs again. Our service gives your existing therapies a new chance to succeed. This service is a key part of our Functional Phage Display Screening platform, where we select molecules based on the real biological results they produce. With our help, you can:
The development of drug resistance is a fundamental challenge in medicine. In oncology, tumors that initially shrink in response to chemotherapy can adapt, developing mechanisms to survive and regrow aggressively. In infectious disease, bacteria evolve defenses that render once-powerful antibiotics useless. This process of acquired resistance is a primary cause of treatment failure and mortality worldwide. Cells achieve resistance through a variety of sophisticated strategies. These can include:
Fig.1 Overcoming drug resistance: mechanisms and therapeutic strategies.1
The central challenge for researchers is not just to develop new drugs, but to find ways to overcome these resistance mechanisms and restore the effectiveness of our existing therapeutic arsenal. This requires identifying novel targets, often on the cell surface, that are critical to the resistant state. A successful therapeutic strategy would involve a molecule that can block these resistance mechanisms, thereby re-sensitizing the cell to a drug it previously ignored. This requires a screening method that can specifically identify molecules with this precise "re-sensitizing" function.
Creative Biolabs provides highly specialized services designed to discover molecules that functionally reverse drug resistance. Our screening systems are built around cellular models of acquired resistance, ensuring that the candidates we identify are directly active against the mechanisms that matter. We focus on delivering molecules that solve the problem of resistance. We offer a direct solution to each form of resistance. Our services are not just about finding molecules that bind; they are about finding molecules that work.
| If your problem is... | Our service provides... |
|---|---|
| Resistant Cancer Cells | Chemosensitizer Discovery. We find antibodies and peptides that, when paired with your cancer drug, successfully kill resistant tumor cells. |
| Resistant Bacteria | Antibiotic Adjuvant Discovery. We identify molecules that disable a bacteria's defenses, making it vulnerable to standard antibiotics once again. |
| An Unknown Resistance Mechanism | New Pathway Discovery. We perform unbiased screens to find molecules that reverse resistance, helping you identify completely new drug targets in the process. |
For oncology research, our goal is to discover potent chemosensitizers. We identify antibodies or peptides that, when paired with a specific cancer drug, can kill tumor cells that have become resistant to that drug alone. This service is designed to create powerful combination therapies, giving established and effective drugs a new lease on life against relapsed or refractory cancers.
In the fight against infectious disease, we focus on discovering antibiotic adjuvants. These are molecules designed to be co-administered with a standard antibiotic. They function by disabling the bacteria's resistance machinery—for example, by blocking an efflux pump or inhibiting a drug-destroying enzyme. This restores the antibiotic's ability to kill the pathogen, providing a critical new weapon against multi-drug resistant "superbugs."
Our platform is not limited to known resistance mechanisms. By using an unbiased functional screen, we can identify molecules that reverse resistance through entirely new targets. This service is invaluable for discovering novel biology and identifying the next generation of targets for anti-resistance drug development.
Our process is designed for clarity and results. We guide your project through four simple and effective phases.
First, we work with you to build the right tool for the job. We create a cell line that is highly resistant to your specific drug. This becomes our test model. We then define a clear goal: find a molecule that helps your drug kill these resistant cells.
Next, we put our phage libraries to the test. We expose your resistant cells to both your drug and our library of billions of molecules. We then apply a simple selection pressure: we only isolate the molecules that succeed in helping your drug kill the cells. This directly enriches for candidates that have the exact function you need.
After finding the successful phages, we identify the molecules they carry. We use our Phage Display NGS Service to get a complete list of all the promising candidates. Our team analyzes this data to select the top performers for the final step.
Finally, we produce the best candidate molecules as pure proteins. We test them to confirm their ability to reverse drug resistance and provide you with detailed data. You receive the sequences, the functional data, and the molecules themselves, ready for your next steps.
Phage display is a technology that uses bacteriophages as a tool for discovery. These viruses must infect bacteria to replicate. There is significant public interest in this field, and phage therapy news often highlights the use of a lytic bacteriophage (one that bursts and kills its host) to treat infections. The concept of phage therapy for antibiotic resistance is a major area of clinical research. While this exciting field of phage therapy antibiotic resistance uses the phage as the therapeutic itself, our application is different. We use the phage as an engineering platform. We genetically modify it to display a human protein—like an antibody fragment—on its surface. This creates a physical link between the protein and its encoding gene. By creating vast libraries containing billions of different phages, we can screen for a desired function and then easily identify the responsible protein. At Creative Biolabs, we provide a structured and comprehensive toolkit to guide your project from a concept to a validated lead molecule. Your journey with us follows a clear and logical path, ensuring every step is optimized for success.
Before the search begins, we ensure you have the best possible tools. This starts with:
With the right library built, we move to the core of the discovery process. Our expert Phage Display Library Screening and Biopanning team executes the functional screen, applying the precise biological pressure needed to isolate your target molecules. The success of this screen depends on performing it in the correct biological context. We select the ideal setting from our versatile suite of Phage Display Screening Platforms:
Your entire discovery journey, from initial design to final delivery, is managed and supported under our comprehensive Phage Display Service. For any goal that falls outside this standard path, our Custom Services Based on Phage Display team is ready to design a completely unique strategy for your project.
We provide clear advantages for your research. Partnering with Creative Biolabs gives you access to a platform built for solving the toughest challenges in drug development.
The molecules we discover are strategic tools that can improve your research.
Many good drugs are no longer used because of resistance. We find partner molecules that block that resistance. This allows you to create a combination therapy that brings an effective drug back into use.
You can use this technology to make today's treatments better. We can find molecules that block common escape routes used by cancer cells or bacteria. Using these molecules alongside a primary drug makes it much harder for resistance to start.
Our service is an engine for creating a new class of "adjuvant" therapies. These molecules are designed with one job: to break the defenses of a resistant cell. They can be developed as new products designed to help other drugs succeed.
Drug resistance is a serious challenge, but it can be overcome. Our platform offers a direct path to finding the molecules that can restore the effectiveness of your therapies. Let's find the solution to your drug resistance problem. today to discuss your project and get a quote.
What types of drug resistance can your platform address?
Our platform is very flexible. We can address resistance to nearly any drug for which we can create a resistant cell model. This includes small molecule chemotherapies, targeted cancer drugs, and all classes of antibiotics. The key is our ability to build a custom test system for your specific project.
How do you know the molecule is reversing resistance and not just toxic?
We confirm this with simple control experiments. We test our candidate molecule alone to ensure it is not toxic. A true resistance-reversing molecule will only show its cell-killing effect when it is combined with your drug, and only on the resistant cells. This proves its specific function.
What do I receive at the end of the project?
You receive a complete and ready-to-use package. This includes the full genetic sequences of your lead molecules, a report on the NGS data, and clear functional data confirming the resistance reversal effect. We also provide pure samples of the molecules for you to use in your own experiments.
What materials do I need to provide to start a project?
Getting started is straightforward. The primary materials needed from you are the drug or compound of interest and the parental cell line (the original, non-resistant cancer cell line or bacterial strain). If you have already developed a resistant version of the cell line, you can provide that as well. However, if you do not have a resistant model, our team will create one for you as the first step of the project.
How long does a typical drug resistance reversal screening project take?
A complete project, from start to final delivery of your validated molecules, typically takes between 4 to 6 months. The initial phase of creating and validating the resistant cell model usually takes 1 to 2 months. The functional screening and enrichment phase requires another 1 to 2 months. The final phase, which includes NGS analysis, hit validation, and data reporting, takes an additional 1 to 2 months. We will provide a detailed project plan with a specific timeline after our initial discussion.
Reference:
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
