The naïve antibody library is a collection of immunoglobulins extracted from lymphoid tissues (bone marrow, spleen and tonsils) or peripheral blood B cells. The gene combination of the natural antibody library can be derived from humans or other animals. Under normal circumstances, a person has at least 108 antibody-producing B-cell clones. The clonal diversity of B-cells allows it to produce different antibody populations, which can target almost all types of antigens. Natural antibody libraries can be used to develop antibodies related to cancer, autoimmune diseases, infectious diseases and other diseases for diagnostic or therapeutic applications. Compared with Immune libraries, natural antibody libraries generally have lower antibody affinity and higher cross-reactivity. This can be solved by constructing a large-scale and diverse antibody library or by in vitro affinity optimization. Creative Biolabs has a wealth of expertise in the field of phage display platform applications. Our scientists can provide high-quality phage display library construction and phage display library screening services.
Creative Biolabs can generate high-diversity antibody libraries for phage display, providing the most sophisticated binding agent for your project. The construction of the naïve library may increase the affinity of the final antibody to the target protein. Our services are listed as follows, but are not limited to:
Screen the selected library by ELISA to determine the high-affinity binding agent of the target protein
Creative Biolabs can meet the needs of customers for providing phage display library construction services on time and on budget. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for each professional for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
