| CAT: | RP-H-TNFR2-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human TNFR2 Protein with C-terminal 6xHis tag |
| Background: | Tumor necrosis factor receptor 2 (TNFR2), often referred to as CD120b and tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), is one of two membrane receptors that binds TNFα. This protein and TNF-receptor 1 create a heterocomplex that recruits two anti-apoptotic proteins, c-IAP1 and c-IAP2, which have E3 ubiquitin ligase activity. Targeting TNRF2 in tumor cells has been linked to increased tumor cell mortality and reduced tumor cell growth progression. Breast cancer, cervical cancer, colon cancer, and kidney cancer all exhibit increased TNFR2 expression. The expression of TNRF2 in tumor cells has been linked to late-stage cancer. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | P20333 |
| Sequence: | Human TNFR2 (Leu 23 - Asp 257) + 6x His tag (N-terminus to C-terminus) |
| Purification: | Protein A/G purified and size-HPLC |
| Purity: | >95% as determined by SDS-PAGE |
| Activity: | Measured by its ability to TNFa with EC50 22.42 ng/ml |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 26 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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