| CAT: | RP-H-TNFR1-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human TNFR1 Protein with C-terminal 6xHis tag |
| Background: | Tumor necrosis factor receptor 1 (TNFR1), often referred to as CD120a and tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), is a common membrane receptor that binds TNFα. This receptor activates NF-κB, mediates apoptosis, and regulates inflammation. Mutations in the TNFRSF1A gene are associated with an increased risk of multiple sclerosis. Serum TNFRSF1A levels are raised in schizophrenia and bipolar disorder, with higher levels associated with more severe psychotic symptoms. High serum levels are also linked to cognitive impairment and dementia. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | P19438-1 |
| Sequence: | Human TNFR1 (Ile 22 - Thr 211) + 6x His tag (N-terminus to C-terminus) |
| Purification: | Protein A/G purified and size-HPLC |
| Purity: | >95% as determined by SDS-PAGE |
| Activity: | Measured by its ability to TNFa with EC50 =12.42 ng/ml |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 22.3 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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