| CAT: | RP-H-PDL1-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human PD-L1 / B7-H1 Protein with C-terminal 6xHis tag |
| Background: | The CD274 gene in humans encodes a protein known as programmed death-ligand 1 (PD-L1), cluster of differentiation 274 (CD274), or B7 homolog 1 (B7-H1). PD-L1 is a type 1 transmembrane protein that suppresses the adaptive arm of immune systems during specific events such as pregnancy, tissue allografts, autoimmune illness, and hepatitis. PD-L1 interacts to the PD-1 receptor, which is located on activated T cells, B cells, and myeloid cells, to control activation or inhibition. PD-L1 binding to PD-1 promotes ligand-induced TCR down-modulation during antigen presentation to naive T lymphocytes by increasing the activity of the E3 ubiquitin ligase CBL-b. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | Q9NZQ7-1 |
| Sequence: | Human PD-1L (Phe 19 - Arg 238) + 6x His tag (N-terminus to C-terminus) |
| Purification: | Affinity and Size-HPLC |
| Purity: | >95% as determined by SDS-PAGE. |
| Activity: | Measured by its binding ability (100 ng) to PD-1 with EC50 =98 ng/ml |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 28 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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