| CAT: | RP-H-MESO-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human Mesothelin Protein with C-terminal 6xHis tag |
| Background: | Mesothelin (MSLN) is a protein found in mesothelial cells. Mesothelin is overexpressed in numerous human cancers, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, lung adenocarcinoma, and cholangiocarcinoma. Mesothelin binds MUC16, implying that the interaction between mesothelin and MUC16 may contribute to tumor implantation and peritoneal dissemination via cell adhesion during cancer development. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | Q13421-3 |
| Sequence: | Human Mesothelin (Glu 296 - Gly 580) + 6x His tag (N-terminus to C-terminus) |
| Purification: | Affinity and Size-HPLC |
| Purity: | >95% as determined by SDS-PAGE. |
| Activity: | Measured by its binding ability (50 ng) to Anti-Human MSLN monoclonal antibody with EC50 =0.36 ng/ml |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 33 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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