| CAT: | RP-H-IL1RAP-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human IL-1 RAcP/IL-1 R3 Protein with C-terminal 6xHis tag |
| Background: | The Interleukin-1 receptor family of proteins includes the widely expressed Interleukin (IL)-1 Receptor Accessory Protein (IL-1 RAcP), also referred to as IL-1 R3. Three signaling pathways involving six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β, and IL-36γ) have IL-1 R3 as a co-receptor. Multiple cytokines play a role in the development of various illnesses. For instance, both IL-33 and IL-1 are crucial in asthma, and IL-36 and IL-1 are crucial in psoriasis. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | Q9NPH3-1 |
| Sequence: | Human IL1RAP (Ser 21 - Glu 359) + 6xHis tag (N-terminus to C-terminus) |
| Purification: | Affinity and size-HPLC |
| Purity: | >95% as determined by SDS-PAGE. |
| Activity: | Measured by its binding ability to human IL-1 RI protein (0.2 µg) and Human IL‑1 beta with an EC50=128 ng/ml. |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | 0.2 µm filtered solution in PBS |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 40 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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