| CAT: | RP-H-FOLR3-6His |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human FOLR3 Protein with C-terminal 6xHis tag |
| Background: | The human folate receptor 1 (FOLR1), also known as folate receptor gamma (FRα), binds to folic acid and its derivatives, which is critical throughout fetal development. FOLR1 is part of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and various reduced folic acid derivatives, and they facilitate the delivery of 5-methyltetrahydrofolate to cell interiors. FOLR1 can be overexpressed in a variety of epithelial malignancies, including ovarian, breast, renal, lung, colorectal, and brain. Antibodies to FOLR1 are being developed for use in targeted therapeutics. |
| Source: | Human 293 cells (HEK293) |
| UniProt ID: | P41439-1 |
| Sequence: | Human FOLR3 (Gln 23 - Ser 245) + 6x His tag (N-terminus to C-terminus) |
| Purification: | Affinity and Size-HPLC |
| Purity: | >95% as determined by SDS-PAGE |
| Activity: | Measured by its binding ability (500 ng) to Folic Acid-BSA with EC50 =0.89 nM |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 26 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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