| CAT: | RP-H-CTLA4-FcHis |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human CTLA-4 Protein with C-terminal human IgG1 Fc & His-tag |
| Background: | Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), also known as cluster of differentiation 152 (CD152), is a protein receptor that acts as an immune checkpoint, inhibiting immune responses. CTLA-4 is constitutively produced in regulatory T cells but only increased in conventional T cells following activation, a characteristic that is especially noticeable in malignancy. When it binds to CD80 or CD86 on antigen-presenting cells' surfaces, it works as a "off" switch. It is encoded by the CTLA4 gene in humans. |
| Source: | Spodoptera frugiperda, Sf 21 (baculovirus)-derived |
| UniProt ID: | Q6GR94 |
| Sequence: | Human CTLA-4 (Ala37-Phe162) + Human IgG1 (Pro100-Lys330) + 6xHis tag (N-terminus to C-terminus) |
| Purification: | Protein A/G purified and size-HPLC |
| Purity: | >95%, by SDS-PAGE. |
| Activity: | Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution: | Reconstitute at 200 μg/mL in sterile PBS. |
| Predicted Molecular Weight: | 40 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
