| CAT: | RP-H-ActRIIB-FcHis |
| Category: | Recombinant Proteins |
| Specifications | |
| Product Name: | Recombinant Human Activin RIIB Protein with C-terminal human IgG1 Fc & His-tag |
| Background: | Activin type 2 receptors are part of a larger TGF-beta receptor family that modulates signals for transforming growth factor beta ligands. These receptors are engaged in a wide range of physiological processes, including growth, cell differentiation, homeostasis, osteogenesis, apoptosis, and many more. The activin type two receptors are ACVR2A and ACVR2B. Activin has a vital impact in reproduction. ACVR2 receptors are found in the testis throughout testicular development. ACR2A and ACVR2B were discovered to be predominantly expressed in gonocytes and sertoli cells. The ACVR2 gene is frequently reported inactive in prostate cancer and tumors with microsatellite instability. |
| Source: | NS0, Mouse myeloma cell line |
| UniProt ID: | Q13705 |
| Sequence: | Human Activin RIIB (Ser19 - Thr134) + Human IgG1 (Pro100-Lys330) + 6xHis tag (N-terminus to C-terminus) |
| Purification: | Protein A/G purified and size-HPLC |
| Purity: | >95%, by SDS-PAGE. |
| Activity: | Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. |
| Endotoxin Level: | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation: | 0.2 µm filtered solution in PBS |
| Reconstitution: | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight: | 41 kDa |
| Shipping: | The product is provided in polar packs. Upon receiving, store it immediately at -20 to -70°C |
| Storage: | Steer clear of frequent freeze-thaw cycles and use a manual defrost freezer. • 12 months from the date of receipt at -20 to -70°C, as specified. • 1 month at 2–8°C under sterile circumstances |
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